Search results for "Normal tissue complication probability"

showing 3 items of 3 documents

A Novel Radiotherapeutic Approach to Treat Bulky Metastases Even From Cutaneous Squamous Cell Carcinoma: Its Rationale and a Look at the Reliability …

2022

IntroductionMetastatic cutaneous squamous cell carcinoma (cSCC) is a very rare condition. The lack of definition of an oligometastatic subgroup means that there is no consensus for its treatment, unlike the mucosal head and neck counterpart. Like the latter, the cutaneous form is able to develop bulky tumor masses. When this happens, the classic care approach is just for palliative intent due to a likely unfavorable benefit–risk balance typical of aggressive treatments. Here we proposed a novel radiotherapy (RT) technique to treat bulky metastases from cSCC in the context of an overall limited tumor burden and tried to explain its clinical outcome by the currently available mathematical rad…

Cancer ResearchOncologycutaneous squamous cell carcinomatumor control probability (TCP)spatially fractionated radiation therapynormal tissue complication probability (NTCP)immunotherapylattice radiotherapybulky tumorsSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)metabolic tumor volume
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External photon radiation treatment for prostate cancer: Uncomplicated and cancer-free control probability assessment of 36 plans

2019

[Purpose] To perform a systematic and thorough assessment, using the Uncomplicated and Cancer-Free Control Probability (UCFCP) function, of a broad range of photon prostate cancer RT treatments, on the same scenario (a unique pelvic CT set). UCFCP considers, together with the probabilities of local tumour control (TCP) and deterministic (late) sequelae (NTCP), the second primary cancer risk (SPCR) due to photon and neutron peripheral doses.

MaleProbability assessmentmedicine.medical_treatmentRadiobiological modellingBiophysicsGeneral Physics and AstronomyProstate radiotherapy treatmentNormal tissue complication probabilityTumour control probabilityRadiation protection of the patient030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancer0302 clinical medicinemedicineHumansDosimetryRadiology Nuclear Medicine and imagingConformal radiationProbabilityPhotonsbusiness.industryRadiotherapy Planning Computer-AssistedCancer-FreePhoton radiationProstatic NeoplasmsRadiotherapy DosageGeneral MedicineSecond primary cancermedicine.diseaseRadiation therapySecond primary cancer risk030220 oncology & carcinogenesisRadiotherapy plan optimisationRadiotherapy Intensity-ModulatedRadiotherapy ConformalTomography X-Ray ComputedNuclear medicinebusinessPhysica Medica 66: 88-96 (2019)
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Analysis of cardiac and pulmonary complication probabilities after radiation therapy for patients with early-stage breast cancer

2009

Objective. The purpose of this study was to evaluate the radiobiological implications of clinical use of respiratory-gated techniques for postoperative radiation therapy of early-stage left-sided breast cancer after breast-conserving surgery. Material and methods. Radiation therapy treatment plans of 80 patients with early-stage breast cancer (stage I–II), receiving whole breast irradiation after breast-conserving therapy, were analyzed. The control group consisting of 47 patients received standard radiation therapy, and the respiratory-gated group consisting of 33 patients received deep inspiration-gated radiation therapy. Normal tissue complication probabilities (NTCP) for cardiac mortali…

medicine.medical_specialtyRespiratory-Gated Imaging TechniquesHeart Diseasesearly-stage breast cancermedicine.medical_treatmentBreast NeoplasmsMastectomy SegmentalStatistics NonparametricCohort StudiesBreast cancerWhole Breast Irradiationnormal tissue complication probabilitymedicineHumansBreastStage (cooking)Radiation Injuriesrespiratory-gated radiotherapyPneumonitisNeoplasm StagingProbabilitybusiness.industryrespiratory-gated radiotherapy; early-stage breast cancer; breast-conserving therapy; normal tissue complication probabilityPatient SelectionRespirationPulmonary ComplicationRadiotherapy DosageGeneral Medicinemedicine.diseaseLatviaSurgeryRadiation therapyRadiation Pneumonitisbreast-conserving therapyFemaleRadiotherapy AdjuvantRadiotherapy ConformalComplicationbusinessTomography X-Ray ComputedMastectomyMedicina
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